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Sunday 30 March 2003

Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug.

By: Ane C, Concordet D.

Stat Med 2003 Mar 30;22(6):833-46

This paper proposes a method for studying the toxicity of an anticancer drug with a delayed effect. The goal is to predict a dosage regimen with controlled toxicity. To this end, a semi-physiological model is used. A limit of toxicity is demonstrated, which is intrinsic to the model. It reduces the effect of high drug concentrations. This limit explains the mixed behaviour of the drug: time-dependence and concentration-dependence, according to the dose actually administered. A population analysis is performed to estimate the parameters of the model, and to predict a safe dosage regimen. Copyright 2003 John Wiley & Sons, Ltd.

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