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Friday 01 November 2002

[Own experiences in salvage chemotherapy of ovarian cancer--a preliminary report]

By: Gerber J, Jedryka M, Gabrys M, Goluda M.

Ginekol Pol 2002 Nov;73(11):1048-52

OBJECTIVE: To compare the efficacy and side effects of the ovarian cancer salvage treatment. MATERIALS AND METHODS: 28 patients from 2nd Department of Gynecology of Wroclaw Medical University, treated for recurrent ovarian cancer in stage III and IV were analyzed. First line treatment after complete debulking operation was based on platinum analogue (CAP). Platinum-sensitive patients were administered carboplatin with paclitaxel in the second line treatment. Platinum-resistant cases were treated with paclitaxel, topotecan or liposomal doxorubicin only. RESULTS: The effectiveness of the salvage chemotherapy was similar. Side effects depended on used agent. CONCLUSIONS: We conclude that the results of salvage treatment in ovarian cancer remain unsatisfactory. Introducing new agents into the therapy slightly improved the overall survival time.

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